{"id":53,"date":"2020-04-18T00:37:28","date_gmt":"2020-04-17T21:37:28","guid":{"rendered":"http:\/\/bogdanoff.net\/?page_id=53"},"modified":"2024-05-24T23:10:04","modified_gmt":"2024-05-24T20:10:04","slug":"science","status":"publish","type":"page","link":"https:\/\/bogdanoff.net\/?page_id=53","title":{"rendered":"Science"},"content":{"rendered":"\n<p>Several years ago, I was on a working trip to Copenhagen. Having walked around the city, tasted the lobster in Nyhavn and pretty wet in the rain, I went to the place from where my colleagues had to pick me up to drive to the airport. But my colleagues got late, and a company of well-drunken Danish students clung to me, who was standing alone on a wet night street. They attacked me with stupid questions, until they found out that I was a scientist. Then they asked: &#171;Scientist \u2026 is it like Niels Bohr or something?&#187; I replied that no, not like that, and generally there are probably no scientiscts like Niels Bohr at the moment. And I doubt they will appear later.<\/p>\n\n\n\n<p>What is the moral of this story? First, I am just the ordinary proletarian of a brainwork. Yes, I have a set of knowledge and skills that most other people don\u2019t have. The same situation is with plumbers, telephone operators and pediatricians. Secondly, yes, in the premodern times (especially during the first 30 years of the twentieth century) science was made by the real titans of thought, amazing at the height and speed of their intellectual flight. Especially Einstein. Now science works in a different way. From a Roman-style columned hall it has turned into a fast-food restaurant. Dinosaurs became extinct, and their niche was replaced by small gray rats. In sum, everything in a stict accord with the evolutionary theory.<\/p>\n\n\n\n<p>Important note. My attitude to doing science is best characterized by the phrase attributed to Professor Artsimovich: &#171;Science is the best way to satisfy personal curiosity at the public accounts.&#187; This means that I am not a career scientist. I\u2019m alien to the model of striving for public recognition in this area (I don\u2019t want to be a head of a huge institute, the president of the Academy of Sciences, to wear furragere, etc). Therefore, here you will see no information about prizes, awards, titles, etc. I have some, but they are not to matter a bit. <em>I suppose that a significant cohort of people (including colleagues of mine) will consider my position to be the loser&#8217;s one. Not going to convince them.<\/em><\/p>\n\n\n\n<p>Another good quote came from the print on one of my t-shirts: &#171;Science is fun!&#187; Also well suited to describe my attitude to the profession. I consider <strong>interest<\/strong> to be the main intrinsic driver of a scientific activity. I have no idols among the scientists (and in general). However, I would refer to Einstein with regard to rationality, and Perelman &#8212; with regard to a &#8216;social pact&#8217; issue.<\/p>\n\n\n\n<p>So, that&#8217;s it with the preface. Time for a face. My scientific projects cover several topics:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Green_fluorescent_protein\">Fluorescent proteins<\/a> photophysics and photochemistry<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Fluorescence-lifetime_imaging_microscopy\">FLIM<\/a> probes and indicators development<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Study of <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959438805000929\">insect chemoreception<\/a> and its application to a mammalian neurobiology <\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Research of the mammalian <a href=\"https:\/\/en.wikipedia.org\/wiki\/Hearing\">hearing<\/a> molecular mechanisms and their application in neurobiliogy<\/li>\n<\/ul>\n\n\n\n<p><strong>UPD as of 2024<\/strong>: The latter direction is rather losing relevance, but new ones are emerging, and I will detail on them as soon as a more substantial progress appears<\/p>\n\n\n\n<p><\/p>\n\n\n\n\n<div class=\"sp-wrap sp-wrap-default\">\n<div class=\"sp-head\" title=\"\u0420\u0430\u0437\u0432\u0435\u0440\u043d\u0443\u0442\u044c\">\nAchievements\n<\/div>\n<div class=\"sp-body folded\">\n<p><b>Main papers<\/b><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2784199\">Bogdanov, A.M., Mishin, A.S., Yampolsky, I.V. &amp; Lukyanov K.A. Green fluorescent proteins are light-induced electron donors. Nature Chem. Biol. 5, 459-461 (2009)<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/nmeth1209-859\">Bogdanov, A.M., Bogdanova, E.A., Chudakov, D.M. &amp; Lukyanov K.A. Cell culture medium affects GFP photostability: a solution. Nature Methods. 6, 859-860 (2009)<\/a><\/p>\n<p><a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0053004\">Bogdanov, A.M., Kudryavtseva, E.I., Lukyanov, K.A. Anti-Fading Media for Live Cell GFP Imaging. PLoS One. 7(12):e53004 (2012)<\/a><\/p>\n<p><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.6b00092\">Bogdanov, A.M., Acharya, A., Titelmayer, A.V. &amp; Krylov, A.I. Turning On and Off photoinduced electron transfer in fluorescent proteins by \u03c0-stacking, halide binding, and Tyr145 mutations. JACS. 138, 4807-17 (2016)<br \/>\n<\/a><\/p>\n<p><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.chemrev.6b00238\">Acharya, A, Bogdanov, A.M., Grigorenko, B.L. &amp; Krylov, A.I. Photoinduced chemistry in fluorescent proteins: Curse or blessing? Chemical Reviews. 117, 758-795 (2017)<br \/>\n<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-018-31687-w\">Mamontova, A.V., Solovyev, I.D., Savitsky, A.P. &amp; Bogdanov, A.M. Bright GFP with subnanosecond fluorescence lifetime. Sci. Rep. 8, 13224 (2018)<\/a><\/p>\n<p><a href=\"https:\/\/www.mdpi.com\/1424-8220\/19\/13\/2982\/htm\">Kost, L.A., Ivanova, V.O., Balaban, P.M. &amp; Bogdanov, A.M. Red Fluorescent Genetically Encoded Voltage Indicators with Millisecond Responsiveness. Sensors. 19, pii: E2982 (2019)<\/a><\/p>\n<p><b>Press releases<\/b><\/p>\n<p><a href=\"http:\/\/www.nature.com\/news\/2009\/090425\/full\/news.2009.401.html#B1\">Green glow deciphered, Nature news<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencenews.org\/article\/function-green-fluorescent-protein\">Function for green fluorescent protein, ScienceNews<\/a><\/p>\n<p><b>Adviser&#8217;s experience<\/b><\/p>\n<p>I was an adviser in two successfully defended PhD projects, and acted as a PI in 17 B.S. and M.S. theses (defended by the students from Moscow State University, Russian National Medical University and Skoltech).<\/p>\n<p>Until recently, I officially supervised the PhD projects of 3 senior PhD-students (all these projects are close to defense). Due to the change of my workplace and country of residence, I am helping them to reach the final stretch remotely. <\/p>\n<p><b>Team and funding<\/b><\/p>\n<p>Until the end of 2023, I had a young research team of up to 10 people in Moscow, Russia. For the last five years, we had at our disposal a well-equipped laboratory and a variety of grants from the Russian Foundation for Basic Research (RFBR) and the Russian Science Foundation (RSF). Since the beginning of 2024, I have started a new life in a new place \ud83d\ude42 I am in the process of building a new laboratory, assembling a team, and attracting funding. To be continued)<\/p>\n<\/div>\n<\/div>\n\n\n\n\n\n<div class=\"sp-wrap sp-wrap-default\">\n<div class=\"sp-head\" title=\"\u0420\u0430\u0437\u0432\u0435\u0440\u043d\u0443\u0442\u044c\">\nPerspective projects\n<\/div>\n<div class=\"sp-body folded\">\n<p><b>Directions to be covered in future<\/b><\/p>\n<p>&#8212; Studies of the longevity molecular determinants in animals with the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Negligible_senescence\">negligible senescence<\/a> <\/p>\n<p>&#8212; Comparative transcriptomics of the human stem cells of the different differentiation potencies, and the malignant cells<\/p>\n<p>&#8212; Transgenic chimeric chemoreceptors in the mammalian CNS<\/p>\n<\/div>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Several years ago, I was on a working trip to Copenhagen. Having walked around the city, tasted the lobster in Nyhavn and pretty wet in the rain, I went to the place from where my colleagues had to pick me up to drive to the airport. But my colleagues got late, and a company of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-53","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/bogdanoff.net\/index.php?rest_route=\/wp\/v2\/pages\/53"}],"collection":[{"href":"https:\/\/bogdanoff.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bogdanoff.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bogdanoff.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bogdanoff.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=53"}],"version-history":[{"count":19,"href":"https:\/\/bogdanoff.net\/index.php?rest_route=\/wp\/v2\/pages\/53\/revisions"}],"predecessor-version":[{"id":1130,"href":"https:\/\/bogdanoff.net\/index.php?rest_route=\/wp\/v2\/pages\/53\/revisions\/1130"}],"wp:attachment":[{"href":"https:\/\/bogdanoff.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=53"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}